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Rapid haemodynamic responses to atrial natriuretic factor (99-126) in conscious sheep
D G Parkes1, J P Coghlan, J G McDougall
1Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
Clinical and Experimental Pharmacology & Physiology
|January 1, 1988
Abstract:
1. Haemodynamic effects of 20 micrograms and 100 micrograms injection of atrial natriuretic factor 99-126 (ANF) were studied in conscious sheep. 2. ANF injection rapidly decreased blood pressure associated with a fall in total peripheral resistance, increased heart rate and cardiac output. These parameters returned to normal within 5 min of injection. 3. This study shows that ANF has an initial vasodilatory action to decrease blood pressure, which is different from the hypotensive mechanism seen with short-term infusion (60 min) of ANF in sheep.