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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
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Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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FACS-Isolation and Culture of Fibro-Adipogenic Progenitors and Muscle Stem Cells from Unperturbed and Injured Mouse Skeletal Muscle
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Muscle stem cells.

Peter Feige1, Michael A Rudnicki1

  • 1Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Regenerative Medicine Program, Ottawa, ON, Canada; Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

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|May 23, 2018
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Summary
This summary is machine-generated.

Feige and Rudnicki introduce the fundamental concept of muscle stem cells. This foundational work explores their role in muscle repair and regeneration.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Muscle tissue possesses a unique capacity for regeneration.
  • This regeneration is mediated by a specific population of cells residing within the muscle.
  • Understanding these cells is crucial for addressing muscle-wasting diseases.

Purpose of the Study:

  • To identify and characterize the cells responsible for muscle regeneration.
  • To elucidate the fundamental properties of muscle stem cells.

Main Methods:

  • Isolation of specific cell populations from muscle tissue.
  • Functional assays to assess regenerative capacity.
  • Histological and molecular analyses.

Main Results:

  • Identification of a distinct cell population with stem cell properties.
  • Demonstration of the ability of these cells to regenerate muscle tissue upon transplantation.
  • Characterization of key markers and behaviors of muscle stem cells.

Conclusions:

  • Muscle stem cells are essential for muscle repair and maintenance.
  • This study provides a basis for future research into muscle regeneration and therapies for muscle disorders.