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Pharmacogenomics steps toward personalized medicine
Hong-Guang Xie1,2, Felix W Frueh1,2
1Vanderbilt University School of Medicine, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Nashville, TN 37232-6602, USA. hong-guang.xie@vanderbilt.edu.
Personalized Medicine
|May 24, 2018
Summary
Pharmacogenomics, the study of how genes affect drug response, is key to personalized medicine. Recent advances enable its clinical use to improve drug efficacy and safety.
Area of Science:
- Pharmacogenomics and Personalized Medicine
Background:
- Interindividual genetic variation significantly impacts disease susceptibility and drug response.
- Translating pharmacogenomic discoveries into clinical practice for personalized medicine has lagged behind scientific advancements.
Purpose of the Study:
- To review current pharmacogenomic findings with high potential for clinical implementation.
- To summarize exploratory examples focusing on drug safety and targeted cancer therapy.
Main Methods:
- Literature review of recent pharmacogenomic research.
- Collating examples for immediate clinical introduction.
- Summarizing exploratory studies in drug safety and oncology.
Main Results:
- Identified numerous pharmacogenomic findings ready for clinical application.
- Highlighted examples with potential for immediate and effective integration into practice.
- Detailed exploratory studies on drug safety and targeted cancer therapies.
Conclusions:
- Pharmacogenomics offers a pathway to maximize therapeutic efficacy and minimize drug toxicity.
- Recent scientific progress supports bolder steps toward implementing personalized medicine.
- The review provides a foundation for advancing pharmacogenomics in clinical settings.
Keywords:
customized medicationgenetic personalizationgene–drug interactionindividualized treatmentmechanism-based therapeuticspersonalized medicinepharmacogeneticspharmacogenomicstailored dosagetargeted therapyMore Related Videos
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