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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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The era of ErbB-receptor-targeted therapies: advances toward personalized medicine

Sarah Bacus1,2,3, Neil L Spector1,2,3, Yosef Yarden1,2,3

  • 1Targeted Molecular Diagnostics LLC, 610 Oakmont Lane, Westmont, IL 6055, USA. sbacus@tmdlab.com.

Personalized Medicine
|May 24, 2018
PubMed

Insights

This review highlights advances in cancer treatment, focusing on the ErbB oncogenic receptor family. Targeting these receptors offers new therapeutic strategies for improved patient outcomes in malignancies like breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Medical Therapeutics

Background:

  • Medical practice focuses on disease diagnosis, prognosis, and treatment.
  • Advances in breast cancer therapy have improved outcomes, but complete chemotherapy response remains limited (10-20%).
  • Understanding cancer's cellular and molecular biology has identified oncogenes and tumor suppressor genes crucial for tumor growth and progression.

Purpose of the Study:

  • To review the role of the ErbB oncogenic receptor family in cancer.
  • To discuss the impact of ErbB receptors on tumor biologic behavior.
  • To highlight ErbB receptors as therapeutic targets for novel treatment strategies.

Main Methods:

  • Literature review of recent advances in cancer biology and therapeutics.
  • Focus on oncogenic receptor families, specifically ErbB.
  • Analysis of therapeutic regimens targeting ErbB receptors.

Main Results:

  • The ErbB oncogenic receptor family significantly influences tumor cell proliferation and cancer progression.
  • Identification of ErbB receptors as key targets for novel therapeutic approaches.
  • New therapeutic strategies targeting ErbB have shown promise in improving treatment response.

Conclusions:

  • The ErbB oncogenic receptor family is a critical target for developing advanced cancer therapies.
  • Targeted therapies against ErbB receptors represent a promising direction for improving patient survival and disease-free intervals.
  • Further research into ErbB-targeted regimens is essential for optimizing cancer treatment.
Keywords:
ErbB receptor familyantibodies to ErbB receptorsoncogenic receptorstargeted therapytyrosine kinase inhibitors

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