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Clinical implementation of psychiatric pharmacogenomic testing
1Mayo Clinic, Department of Psychiatry and Psychology, 200 First Street, SW Rochester, Minnesota 55905, USA;;E-mail: . mrazek.david @mayo.edu.
Personalized Medicine
|May 24, 2018
Summary
Psychiatrists are now using genetic testing to guide psychotropic medication selection and dosing. This pharmacogenomic approach focuses initially on drug-metabolizing enzyme genes for personalized psychiatric care.
Area of Science:
- Pharmacogenomics
- Psychiatric Genetics
- Clinical Pharmacology
Background:
- Psychiatry has anticipated the clinical application of genetic testing for several years.
- The integration of genotyping into psychiatric practice is now becoming a reality.
Purpose of the Study:
- To introduce the initial clinical applications of genotyping in psychiatric practice.
- To highlight the role of genetic information in guiding psychotropic medication selection and dosing.
Main Methods:
- Clinical genotyping of drug-metabolizing enzyme genes.
- Application of genetic data to inform psychotropic drug selection.
- Utilizing genetic profiles to personalize medication dosage.
Main Results:
- The first clinical applications of genotyping are being implemented in psychiatry.
- Drug-metabolizing enzyme genes are the primary focus for initial clinical genotyping.
- Genotyping is informing individual variation in psychotropic medication response and dosage.
Conclusions:
- Genotyping is emerging as a valuable tool in clinical psychopharmacology.
- Personalized medicine in psychiatry is advancing through pharmacogenomic applications.
- The initial focus on drug-metabolizing enzymes facilitates tailored psychiatric treatment strategies.
Keywords:
CYP2D6 substrate medicationscytochrome P450 genotypedrug-metabolizing enzyme genespoor metabolizerultra-rapid metabolizerMore Related Videos
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