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The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
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Feline injection site sarcoma: immunohistochemical characteristics.
Carolina S Carneiro1, Genilson F de Queiroz2, Ana Cbcf Pinto1
11 Department of Veterinary Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
Journal of Feline Medicine and Surgery
|May 24, 2018
Summary
This study details the immunohistochemical characteristics of feline injection site sarcomas (FISS). Key findings include positive vimentin and S-100 protein expression in most FISS, aiding in understanding these aggressive feline tumors.
Area of Science:
- Veterinary Pathology
- Oncology
- Immunohistochemistry
Background:
- Feline injection site sarcoma (FISS) is a locally aggressive tumor in cats.
- Histologic features are defined, but immunohistochemical characteristics are less understood.
- Few studies have investigated the specific markers in FISS.
Purpose of the Study:
- To investigate the immunohistochemical characteristics of 21 feline injection site sarcoma (FISS) cases.
- To identify potential markers for FISS diagnosis and understanding.
- To contribute to the limited existing literature on FISS immunohistochemistry.
Main Methods:
- Histopathological diagnosis of 21 FISS cases.
- Immunohistochemical staining for vimentin, cytokeratin, desmin, S100 protein, FeLV, COX-2, and c-KIT.
- Classification of immunostainings based on positive cell count.
Main Results:
- All FISS samples were positive for vimentin (100%).
- S-100 protein was positive in 95.2% of cases.
- COX-2 (61.9%) and FeLV viral particles (42.9%) showed variable positivity, while c-KIT was positive in 19%.
Conclusions:
- Immunohistochemical analysis revealed characteristic marker expression in FISS.
- Vimentin and S-100 protein are consistently expressed in FISS.
- Findings provide insights into FISS markers, including COX-2 and FeLV, relevant for veterinary oncology.
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