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Biologics for the Treatment of Juvenile Idiopathic Arthritis

Dimitri Poddighe1, Micol Romano2, Maurizio Gattinara2

  • 1Department of Medicine, School of Medicine, Nazarbayev University, Kerei-Zhanibek Str. 5/1, Astana, 010000, Kazakhstan.

Current Medicinal Chemistry
|May 24, 2018
PubMed

Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic diseases in children. Recently, the management of JIA has substantially changed, thanks to the availability of new treatment options, represented by biological drugs or biologics. These drugs modulate the specific mechanisms of the immune systems, such as TNF-α, IL-1 and IL-6 signaling, or lymphocyte activation and/or functioning. In this review, we provide a comprehensive discussion on the current recommendations and clinical evidence regarding the use of the available biologics in the treatment of JIA; moreover, the main pharmacokinetic and pharmacodynamic aspects of any specific biologic drug have been summarized.

Keywords:
BiologicsJIAclinical evidenceimmunologypharmacodynamicspharmacokinetics.

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