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Engineering Aspects of Protein Interactions and Self-assembly
Miriam Linsenmeier1, Paolo Arosio2
1ETH Zurich Department of Chemistry and Applied Biosciences Institute for Chemical and Bioengineering, Vladimir Prelog Weg 1, CH-8093 Zurich.
Chimia
|May 24, 2018
Summary
Researchers at ETH Zurich
Area of Science:
- Biochemical Engineering
- Biophysics
- Biotechnology
Background:
- Biomolecular self-assembly is crucial for life.
- Understanding its physical determinants is key for applications.
- Protein aggregation and phase separation are critical processes.
Purpose of the Study:
- Investigate physical determinants of biomolecular self-assembly.
- Explore applications in biomedical sciences and biotechnology.
- Focus on protein aggregation and phase separation.
Main Methods:
- Combining chemical engineering principles.
- Utilizing microfluidic technology.
- Applying biophysical methods.
Main Results:
- Demonstrated impact on biomedical and biotech applications.
- Highlighted relevance in Alzheimer's disease and neurodegenerative disorders.
- Showcased applications in cell compartmentalization and therapeutic protein manufacturing/delivery.
Conclusions:
- The Laboratory for Biochemical Engineering (LBCE) advances understanding of biomolecular self-assembly.
- This research has significant implications for disease diagnosis, treatment, and biotechnology.
- Microfluidics and biophysics are powerful tools for these investigations.
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