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Frizzled Receptors as Potential Therapeutic Targets in Human Cancers

Chui-Mian Zeng1, Zhe Chen2, Li Fu3

  • 1Guangdong Key Laboratory for Genome Stability & Disease Prevention, Department of Pharmacology and Carson International Cancer Research Centre, Shenzhen University School of Medicine, Shenzhen 518060, China. 2160220126@email.szu.edu.cn.

International Journal of Molecular Sciences
|May 24, 2018
PubMed

Insights

Frizzled receptors (FZDs), key in WNT signaling, are crucial for cell functions and cancer progression. This review explores FZD roles in cancer and their therapeutic potential using targeted inhibitors and antibodies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Frizzled receptors (FZDs) are transmembrane receptors essential for WNT signaling.
  • FZDs regulate critical cellular processes including development, polarity, and proliferation.
  • Dysregulation of FZDs is implicated in various human cancers.

Purpose of the Study:

  • To review the structural features, biological functions, and mechanisms of FZDs in human cancer progression.
  • To analyze the clinical relevance and therapeutic potential of targeting FZDs in oncology.
  • To focus on developing antibody-based and small molecule inhibitor-based strategies against FZDs for cancer treatment.

Main Methods:

  • Literature review of FZD structure and function.
  • Analysis of FZD roles in cancer cell biology and signaling pathways.
  • Review of current and emerging therapeutic strategies targeting FZDs.

Main Results:

  • FZDs are integral to WNT pathway activation, influencing cell fate and behavior.
  • Aberrant FZD signaling contributes to tumorigenesis, metastasis, and drug resistance.
  • Targeting FZDs shows promise for novel cancer therapies.

Conclusions:

  • FZDs represent significant targets for cancer therapy due to their roles in WNT signaling and cancer progression.
  • Therapeutic strategies involving antibodies and small molecule inhibitors offer potential for effective cancer treatment by modulating FZD activity.
Keywords:
WNT signaling pathwayantibodycancer therapyfrizzled receptorssmall molecule inhibitor

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