Impact of Static Magnetic Field on the Antioxidant Defence System of Mice Fibroblasts

Results of research assessing the biological impact of static magnetic fields are controversial. So far, they have not provided a clear answer to their influence on cell functioning. Since the use of permanent magnets both in everyday life and in industry becomes more and more widespread, the investigations are continued in order to explain these controversies and to evaluate positive applications. The goal of current work was to assess the impact of static magnetic field of different intensities on redox homeostasis in cultures of fibroblasts. The use of permanent magnets allowed avoiding the thermal effects which are present in electromagnets. During the research we used 6 chambers, designed exclusively by us, with different values of field flux density (varying from 0.1 to 0.7 T). We have noted the decrease in the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx). The static magnetic fields did not modify the energy state of fibroblasts- adenosine triphosphate (ATP) concentration was stable, as well as the generation of malondialdehyde (MDA)-which is a marker of oxidative stress. Results of research suggest that static magnetic fields generated by permanent magnets do not cause oxidative stress in investigated fibroblasts and that they may show slight antioxidizing activity.