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[Oncogenes and oncogene products in urogenital cancer cells]
N Deguchi1, M Tachibana, H Tazaki
1Department of Urology, School of Medicine, Keio University.
Abstract:
Recent development in microbiology and genetic engineering has provided the identification and characterization of so-called 'oncogenes'. The concept of oncogenes has much stimulated intense interest in searching the cause of uncontrolled cell growth and factors responsible for formation of tumors. Because of the fact that oncogenes were first discovered in an established cell line derived from patient with bladder tumor, the association between oncogenes and genitourinary cancer has much attention. Variety of pathways of tumor development in bladder cancer can be divided in two major forms, low grade papillary tumor and high grade infiltrating tumor. Activation and a sequence of oncogenes may be relevant to the ultimate expression of these separate pathways. Concept of initiation and promotion may also be factored into these consideration. The application of these principles to the different pathways of tumor development such as in bladder, kidney and prostate cancers, supports the concept that oncogenes may be required to production of malignant tumors. The purpose of this paper is to review recent evidence that has enhanced our understanding of the genetic basis of cancer development in the genitourinary tract cancer.
Insights
Oncogenes, identified through advancements in microbiology and genetic engineering, are key to understanding uncontrolled cell growth and tumor formation. Their role in genitourinary cancers like bladder, kidney, and prostate is increasingly evident.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Context:
- Oncogenes, identified via microbiology and genetic engineering, are implicated in uncontrolled cell growth.
- Initial discovery linked oncogenes to bladder tumors, prompting research into genitourinary cancers.
- Tumor development in bladder cancer presents distinct pathways, including low-grade papillary and high-grade infiltrating forms.
Purpose:
- To review recent evidence on the genetic basis of genitourinary tract cancers.
- To explore the association between oncogenes and the development of bladder, kidney, and prostate cancers.
- To understand how oncogene activation contributes to distinct tumor development pathways.
Summary:
- Oncogene activation and sequencing are potentially relevant to the distinct pathways of bladder cancer progression.
- The principles of tumor initiation and promotion are considered in relation to oncogene function.
- Evidence suggests oncogenes are required for the production of malignant tumors in the genitourinary tract.
Impact:
- Enhanced understanding of the genetic underpinnings of genitourinary cancers.
- Provides a foundation for future research into targeted therapies for these malignancies.
- Highlights the critical role of oncogenes in cancer etiology and progression.