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Updated: Feb 10, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
Published on: March 6, 2013
Influenza A M2 transmembrane domain tunes its conformational heterogeneity and structural plasticity in the lipid
Yue Liu1, Junjun Tan, Jiahui Zhang
1Hefei National Laboratory for Physical Sciences at the Microscale, and Synergetic Innovation Center for Quantum Information & Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026, China. shujiye@ustc.edu.cn.
Abstract:
We discovered for the first time that the influenza A virus M2TM tunes its conformational heterogeneity and structural plasticity to respond to environmental cues by undergoing a helix-to-loop transition, resolving controversies regarding the mechanism of proton conduction and plasticity of the M2TM in lipid bilayers.
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