Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mean free path and Mean free time01:22

Mean free path and Mean free time

5.2K
Consider the gas molecules in a cylinder. They move in a random motion as they collide with each other and change speed and direction. The average of all the path lengths between collisions is known as the "mean free path."
5.2K
Path Between Thermodynamics States01:21

Path Between Thermodynamics States

4.1K
Consider the two thermodynamic processes involving an ideal gas that are represented by paths AC and ABC in Figure 1:
4.1K
Rationalizing Substitutions01:29

Rationalizing Substitutions

62
Integrals involving non-rational functions are often difficult to evaluate using standard techniques, especially when radicals appear in the integrand. Rationalizing substitution provides a systematic method for simplifying such integrals by converting them into rational forms that are easier to handle.Consider a rod whose linear mass density depends on a constant linear density, a characteristic length, and the distance from the left end of the rod. Determining the total mass requires...
62
Rational Expressions01:28

Rational Expressions

409
Rational expressions are algebraic fractions in which both the numerator and the denominator are polynomials. These expressions follow the arithmetic rules of numerical fractions but require extra care due to the presence of variables. A fundamental part of working with rational expressions is identifying values that make the expression undefined, typically those that result in division by zero or undefined radicals.Determining the DomainThe domain of a rational expression includes all real...
409
Interference: Path Lengths01:10

Interference: Path Lengths

2.2K
Consider two sources of sound, that may or may not be in phase, emitting waves at a single frequency, and consider the frequencies to be the same.
Two special sources may be considered when they are in phase. This can be easily achieved by feeding the two sources from the same source. An example would be synchronizing the two speakers by feeding them with the same source, such as the sound waves produced by a tuning fork. This setup ensures that the two sources have the same frequency and are...
2.2K
Asymptotes in Rational Functions01:30

Asymptotes in Rational Functions

266
A rational function is defined as the quotient of two polynomials:  where Q(x)≠0, These functions often exhibit asymptotes, which are the lines that the graph approaches but never touches. These asymptotes are classified based on how the function behaves near specific values of the input.Vertical asymptotes occur where the denominator is zero, and the numerator is not, causing the function to be undefined. These are found by solving Q(x)=0. For example:  has a vertical...
266

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The case for allele-specific recognition by the TCR.

Scandinavian journal of immunology·2019
Same author

The real "danger" lies in the failure to confront fundamentals.

Scandinavian journal of immunology·2018
Same author

TCR-pMHC interactions: Two peptide repertoires-one signal.

Scandinavian journal of immunology·2018
Same author

Somatic diversification of the B cell repertoire requires two cell subsets.

Scandinavian journal of immunology·2018
Same author

History of the antibody workshops.

Immunologic research·2017
Same author

An observation that illustrates most T cell receptor structure-function relationships.

Immunologic research·2017
Same journal

Emapalumab plus conventional therapy with or without ruxolitinib for pediatric hemophagocytic lymphohistiocytosis: a single center retrospective study.

Immunologic research·2026
Same journal

Immunological spectrum in patients with thymoma: beyond good syndrome.

Immunologic research·2026
Same journal

Microbiome immune crosstalk in Sjögren's syndrome: mechanistic insights and translational perspectives.

Immunologic research·2026
Same journal

Immune checkpoint inhibitor-induced myasthenia gravis and myocarditis: a fatal immune-related adverse event.

Immunologic research·2026
Same journal

TRIM28 and TRIM32: multifaceted regulators of innate immunity and antiviral defence.

Immunologic research·2026
Same journal

Decoding PANoptosis: Crosstalk of cell death pathways in immunity and inflammation.

Immunologic research·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

14.2K

Rationalizing the path to a universal graft recipient.

Melvin Cohn1

  • 1Conceptual Immunology Group, The Salk Institute, 10010 N. Torrey Pines Rd., La Jolla, CA, 92037, USA. cohn@salk.edu.

Immunologic Research
|May 24, 2018
PubMed
Summary
This summary is machine-generated.

Universal graft acceptance may be achievable by controlling T-helper cells, a key component of the immune system. This approach builds upon decades-old experimental findings to offer a general solution for preventing organ transplant rejection.

Keywords:
ChimerismSuppressionTCR structure-functionTissue transplantation

More Related Videos

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.5K
A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

10.9K

Related Experiment Videos

Last Updated: Feb 10, 2026

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

14.2K
Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.5K
A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
12:18

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

10.9K

Area of Science:

  • Immunology
  • Transplantation Biology
  • Medical Research

Background:

  • Graft rejection remains a significant challenge in organ transplantation.
  • Decades-old experimental data provides foundational insights into immune responses.
  • Understanding immune system regulation is crucial for transplant success.

Purpose of the Study:

  • To explore the logical pathway towards achieving universal graft acceptance.
  • To re-evaluate and expand upon historical experimental findings in transplantation.
  • To identify a targeted immunomodulatory strategy for general graft acceptance.

Main Methods:

  • Review and in-depth analysis of historical immunological experiments.
  • Logical deduction and theoretical modeling of immune system interactions.
  • Focus on the role of specific immune cell populations in graft rejection.

Main Results:

  • Historical data suggests a potential for universal graft acceptance.
  • Analysis points to T-helper cells as a critical regulatory point.
  • Controlling T-helper cell activity is identified as a promising strategy.

Conclusions:

  • Targeting T-helper cell function offers a viable path to universal graft acceptance.
  • This immunomodulatory approach could overcome current transplantation limitations.
  • Further research into T-helper cell modulation is warranted for clinical application.