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Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images
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Variability of native T1 values: implication for defining regional myocardial changes using MRI.

Kai Lin1, Kenichiro Suwa2, Heng Ma2

  • 1Department of Radiology, Northwestern University, 737 N Michigan Avenue, Suite 1600, Chicago, IL, 60611, USA. kai-lin@northwestern.edu.

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Summary

This study establishes T1 variation (T1v) thresholds for cardiac MRI T1 mapping in the left ventricle. These thresholds help differentiate true disease effects from measurement variability in T1 values.

Keywords:
MOLLIMRIMyocardiumNative T1 variation

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Area of Science:

  • Cardiovascular Imaging
  • Medical Physics
  • Quantitative MRI

Background:

  • T1 mapping using cardiac Magnetic Resonance Imaging (MRI) is crucial for assessing myocardial tissue characteristics.
  • Establishing reliable T1 variation (T1v) thresholds is essential for accurate interpretation of T1 measurements and disease detection.
  • Reproducibility of T1 measurements is influenced by factors like spatial resolution, intra-observer, inter-observer, and inter-study variability.

Purpose of the Study:

  • To establish T1 variation (T1v) thresholds for duplicated regional T1 measurements in the left ventricle (LV) using cardiac MRI.
  • To determine the reliability and reproducibility of T1 mapping using the modified Look-Locker Inversion recovery (MOLLI) sequence under various conditions.
  • To provide quantitative benchmarks for distinguishing disease-induced T1v from random measurement errors.

Main Methods:

  • Eighteen healthy volunteers underwent two consecutive cardiac MRI scans using the MOLLI sequence at two spatial resolutions on different days.
  • Regional T1 values in the LV were measured twice by two independent readers.
  • T1 variation thresholds were calculated using the formula: mean difference + 2 * Standard Deviation (SD), alongside intra-class correlation coefficients (ICCs) and coefficients of variation (CoVs).

Main Results:

  • High intra-observer ICCs (0.988 per slice, 0.974 per segment) indicate excellent within-reader reproducibility.
  • Inter-study ICCs were lower (0.6 per slice, 0.594 per segment), suggesting variability across different scanning sessions.
  • Calculated T1v thresholds ranged from 22 ms (per slice) to 144 ms (per segment), depending on the analysis level and variability source.

Conclusions:

  • The established T1v thresholds provide a quantitative basis for interpreting T1 mapping results in the left ventricle.
  • These thresholds can aid in differentiating true pathological T1 variations from inherent measurement uncertainties in cardiac MRI.
  • The findings support the clinical utility of MOLLI-based T1 mapping for quantitative myocardial tissue characterization.