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Updated: Feb 10, 2026

Colletotrichum fioriniae Development in Water and Chloroform-based Blueberry and Cranberry Floral Extracts
Published on: April 12, 2019
Anticancer activity of chlorhexidine and cranberry extract: an in-vitro study
Mahesh R Khairnar1, Umesh Wadgave1, Harish Jadhav2
1Department of Public Health Dentistry, Bharati Vidyapeeth Deemed University Dental College & Hospital, Sangli, Maharashtra, India.
Introduction:
Oral cancer is considered to be a global pandemic. The study was conducted to assess the anti-cancer activities of Chlorhexidine (CHX) and Cranberry against oral cancer cell lines.
Material And Methods:
Anticancer activity of CHX and Cranberry extract (CE) was assessed against AW13516 (poorly to moderately differentiated squamous cell carcinoma of tongue) and KB (Nasopharyngeal carcinoma) using Sulforhodamine B (SRB) assay at the Advanced Centre for Treatment Research and Education in Cancer (ACTREC) Mumbai, India. Three dose related parameters GI50, TGI and LC50 were calculated for each drug.
Results:
CE (80µg/ml) showed no anti-cancer property against AW13516 cell line; however it showed 70.6% growth inhibition against KB cell line. CHX demonstrated 80.15% & 95.7% of growth inhibition against AW13516 & KB cell line respectively. Both the drugs were less potential than positive control drug Adriamycin, as reflected by their GI50, TGI and LC50 values.
Conclusion:
CHX exhibited better anti-cancer properties than CE for both the oral cancer cell lines.
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