Related Experiment Video

Updated: Feb 10, 2026

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
10:21

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

7.7K

Inhibitory effects of mushroom extracts on progression of carcinogenesis in mice

Caroline Wasonga1, Charles Omwandho2

  • 1Department of Biochemistry, University of Nairobi, P.O. Box 30197-00100, GPO, Nairobi, Kenya.

Journal of Experimental Therapeutics & Oncology
|May 24, 2018
PubMed
Abstract

Insights

Agaricus bisporus mushroom extracts show promise in slowing hepatocellular carcinoma progression in mice. Supplementing with these extracts may aid conventional cancer therapies by protecting liver cells.

Area of Science:

  • Hepatocellular carcinoma research
  • Natural product pharmacology
  • Chemoprevention studies

Background:

  • Hepatocellular carcinoma (HCC) is a significant global health concern.
  • Natural products, including mushrooms, are explored for anti-cancer properties.
  • Investigating dietary interventions for HCC management is crucial.

Purpose of the Study:

  • To evaluate the impact of Agaricus bisporus extracts on chemically induced liver carcinogenesis in mice.
  • To assess the chemopreventive potential of common mushrooms in HCC progression.

Main Methods:

  • Carcinogenesis was induced in mice.
  • Mice were administered Agaricus bisporus extracts.
  • Tumor progression was monitored using lactate dehydrogenase and sialic acid levels, alongside histological analysis.

Main Results:

  • Sialic acid levels decreased in mice fed mushroom extracts, unlike lactate dehydrogenase.
  • Histological examination revealed hepatocyte protection against carcinogenesis.
  • Agaricus bisporus extracts demonstrated a slowing effect on carcinogenesis progression.

Conclusions:

  • Agaricus bisporus extracts may serve as a beneficial dietary supplement for HCC.
  • These mushroom extracts show potential in supporting conventional cancer treatments.
  • Further research into mushroom-based therapies for liver cancer is warranted.
Keywords:
Agaricus bisporusCarcinogenesisHepatocellular carcinoma

More Related Videos

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice11:16

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

22.8K
Detection of Lung Tumor Progression in Mice by Ultrasound Imaging04:43

Detection of Lung Tumor Progression in Mice by Ultrasound Imaging

Published on: February 27, 2020

7.4K

Related Concept Videos

Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
13.1K
Extraction: Effects of pH00:53

Extraction: Effects of pH

Consider a neutral form of an amine, B, with a partition coefficient, K, in a liquid mixture containing organic and aqueous phases. The pH of the aqueous phase affects the charge on acidic and basic solutes, and the charged form is usually more soluble in the aqueous phase. Suppose the conjugate acid form of the amine is soluble only in the aqueous phase while the base form is soluble in both phases. Then the distribution coefficient, D, can be given as the ratio of amine concentration in the...
1.4K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
Buffer Effectiveness02:19

Buffer Effectiveness

Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
The buffer capacity is the amount of acid or base that can be added to a given volume...
55.5K
Framing Effects03:26

Framing Effects

Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
8.0K