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Systematic evaluation of clinical practice guidelines for pharmacogenomics
Robert D Beckett1, David F Kisor2, Thomas Smith3
1Manchester University Doctor of Pharmacy Program, Department of Pharmacy Practice, 10627 Diebold Rd, Fort Wayne, IN 46845, USA.
Pharmacogenomics
|May 24, 2018
Summary
The methodological quality of pharmacogenomics clinical practice guidelines was assessed using the AGREE II instrument. While generally high, the quality scores showed variability across different domains.
Area of Science:
- Pharmacogenomics
- Clinical Practice Guidelines
- Methodological Quality Assessment
Background:
- Pharmacogenomics (PGx) is crucial for personalized medicine.
- Clinical practice guidelines (CPGs) guide the integration of PGx into healthcare.
- Systematic assessment of PGx CPG quality is needed.
Purpose of the Study:
- To systematically evaluate the methodological quality of pharmacogenomics clinical practice guidelines.
- To identify strengths and weaknesses in existing PGx guidelines.
Main Methods:
- A systematic review of PGx guidelines published up to 2017.
- Utilized the Appraisal of Guidelines for Research & Evaluation II (AGREE II) instrument.
- Involved assessment by at least three independent reviewers using a 7-point rating scale.
Main Results:
- 31 PGx guidelines were included in the analysis.
- Mean AGREE II domain scores varied, with 'applicability' scoring lowest (46.6%) and 'clarity of presentation' highest (78.9%).
- The median overall quality score was 72.2%.
Conclusions:
- Pharmacogenomics guidelines demonstrate generally high methodological quality.
- Variability in quality across AGREE II domains suggests areas for improvement.
- Ensuring consistent quality is essential for effective implementation of pharmacogenomics.
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