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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Published on: December 30, 2016
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Hyperpolarized NMR Spectroscopy: d-DNP, PHIP, and SABRE Techniques
Kirill V Kovtunov1,2, Ekaterina V Pokochueva1,2, Oleg G Salnikov1,2
1Laboratory of Magnetic Resonance Microimaging, International Tomography Center, Siberian Branch of Russian Academy of Sciences (SB RAS), 3A Institutskaya St., Novosibirsk, 630090, Russia.
Chemistry, an Asian Journal
|May 24, 2018
Summary
Hyperpolarization techniques significantly boost Nuclear Magnetic Resonance (NMR) signal intensity, overcoming sensitivity limits in NMR and MRI. This review covers methods like dissolution dynamic nuclear polarization (d-DNP) and parahydrogen-based approaches for hyperpolarized fluids in science and medicine.
Area of Science:
- Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI)
- Molecular Spectroscopy
- Biomedical Imaging and Material Science
Background:
- NMR/MRI techniques face inherent sensitivity limitations.
- Hyperpolarization offers a powerful solution to enhance signal intensity.
- Hyperpolarized fluids have diverse applications in material science and biomedicine.
Purpose of the Study:
- To review the fundamentals of preparing hyperpolarized liquids and gases.
- To discuss various hyperpolarization techniques, including d-DNP, SABRE, and PHIP.
- To explore new aspects in the formation and utilization of hyperpolarized fluids.
Main Methods:
- Dissolution dynamic nuclear polarization (d-DNP).
- Parahydrogen-based techniques: Signal Amplification By Reversible Exchange (SABRE) and Parahydrogen-Induced Polarization (PHIP).
- Both heterogeneous and homogeneous preparation processes are considered.
Main Results:
- NMR signal enhancement by several orders of magnitude is achievable.
- Overcomes major sensitivity challenges in NMR and MRI.
- Enables observation of enhanced NMR signals from hyperpolarized fluids.
Conclusions:
- Hyperpolarization is crucial for advancing NMR/MRI sensitivity.
- d-DNP and parahydrogen-based methods are key techniques for preparing hyperpolarized fluids.
- New developments expand the utility of hyperpolarized fluids in scientific and medical applications.
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