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A decreasing function describes a relationship where the output consistently declines as the input increases. This means that for any two input values, if one is greater than the other, the corresponding output is smaller. Mathematically, a function f is decreasing on an interval I if for every x1 < x2​ in I, f (x1) > f (x2). This type of behavior is visually identified on a graph that slopes downward from left to right.The nature of a function can be analyzed by calculating...
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Age associated decrease of sialin in salivary glands.

L Li1,2, H Wang1,3, L Hu1

  • 1a Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction , Capital Medical University School of Stomatology , Beijing.

Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission
|May 24, 2018
PubMed
Summary
This summary is machine-generated.

Aging reduces sialin (an anion transporter) expression in salivary glands, potentially impacting saliva flow and function. This study examined age-associated changes in sialin levels in mouse and human salivary glands.

Keywords:
agingcellular locationhumanmousesalivary glandsialin

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Area of Science:

  • Salivary gland biology
  • Aging research
  • Molecular transport mechanisms

Background:

  • Aging salivary glands exhibit reduced acinar volume, increased ductal volume, and decreased saliva production.
  • Sialin, an anion transporter highly expressed in salivary glands, may be crucial for maintaining gland function.

Purpose of the Study:

  • To investigate the age-associated changes in sialin expression within salivary glands.
  • To correlate sialin expression patterns with aging-related functional declines in salivary glands.

Main Methods:

  • Analysis of sialin protein and mRNA levels in mouse submandibular and human parotid glands across different ages.
  • Utilized Western blot, real-time RT-PCR, immunohistochemistry, and immunofluorescence staining.

Main Results:

  • Both sialin protein and mRNA expression significantly decreased with aging in both mouse and human salivary glands.
  • Age-related reductions in sialin expression were observed in the striated and excretory ducts.
  • Sialin expression in acinar and myoepithelial-like cells diminished in aged glands compared to younger ones.

Conclusions:

  • Age-associated decline in sialin expression is evident in salivary glands.
  • Altered sialin expression may contribute to the functional changes observed in salivary glands during aging.