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Incidence of childhood Type 1 diabetes mellitus in Crete
D Mamoulakis1, F Vrouvaki1, V Louvari1
1Department of Paediatrics, Heraklion University Hospital, Crete, Greece.
Insights
Childhood Type 1 diabetes incidence in Crete shows a concerning 4.4% annual increase, particularly in older children. This trend aligns with global patterns, classifying Crete as a high-incidence region.
Area of Science:
- Pediatrics
- Endocrinology
- Epidemiology
Background:
- Type 1 diabetes mellitus (T1DM) is a significant global health concern in children.
- Understanding regional incidence trends is crucial for public health planning and resource allocation.
Purpose of the Study:
- To investigate the epidemiology of childhood T1DM in Crete over a 25-year period (1992-2016).
- To evaluate temporal trends in T1DM incidence among children on the island.
Main Methods:
- Retrospective analysis of all diagnosed T1DM cases in children aged 0-14 years residing in Crete.
- Data collected from January 1, 1992, to December 31, 2016.
Main Results:
- 271 children diagnosed with T1DM (148 boys, 123 girls).
- Standardized annual incidence rate of 10.5 per 100,000 children, peaking in the 5-9 age group.
- An average annual increase of 4.4% in incidence observed over 25 years, most pronounced in ages 5-14.
Conclusions:
- Crete exhibits a high incidence of childhood T1DM, consistent with WHO classifications.
- The documented rising incidence trends in Crete mirror global patterns of T1DM increase.
Aim:
To investigate the epidemiology of childhood Type 1 diabetes mellitus in Crete over the last 25 years and to evaluate incidence trends over time.
Methods:
The study included all children aged 0-14 years who live in Crete and were diagnosed during the 25-year period from 1 January 1992 to 31 December 2016.
Results:
A total of 271 children were diagnosed with Type 1 diabetes during the 25-year period: 148 boys and 123 girls (boy:girl ratio 1.2). The median (interquartile range) age at diagnosis was 8.3 (5.0-12.0) years for boys and 8.0 (5.3-11.3) years for girls. The standardized annual incidence rate was 10.5 per 100 000 children (95% CI 9.2 to 11.8). Incidence rates were higher in children aged 5-9 years. During the 25-year study period an average 4.4% annual increase in incidence was documented and was most prominent in the age group 5-14 years. Incidence seemed to remain relatively stable for the age group 0-4 years in the last decade. No seasonality of the clinical onset of Type 1 diabetes was observed.
Conclusions:
The recent increase in Type 1 diabetes incidence places Crete among regions with high incidence as per the World Health Organization DiaMond project classification. The rising trends in incidence confirmed by this study are in accordance with the reported global trends in Type 1 diabetes incidence.
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