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Related Concept Videos

Self-Presentation01:25

Self-Presentation

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Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
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People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
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Strategies of Self-Presentation I: Strategic Self-Presentation01:12

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Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
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Processes of Self-Presentation01:29

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Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
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Ligand Binding Sites02:40

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
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Accessing the Cytotoxicity and Cell Response to Biomaterials
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Dynamic Ligand Presentation in Biomaterials.

Joshua A Hammer1, Jennifer L West1

  • 1Department of Biomedical Engineering , Duke University , 101 Science Drive , Campus Box 90281, Durham , North Carolina 27708-0281 , United States.

Bioconjugate Chemistry
|May 24, 2018
PubMed
Summary
This summary is machine-generated.

Controlling biochemical cues in the cell microenvironment is key for tissue engineering. This review explores methods for dynamic control of bioactive ligand presentation in biomaterials, including light-activated genetic approaches.

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • The native cell microenvironment involves dynamic interactions between cells and the extracellular matrix.
  • These interactions regulate critical physiological processes like cell migration, stem cell differentiation, and tissue formation.
  • Delivering precise biochemical cues is essential for achieving specific biological outcomes in vitro and in vivo.

Purpose of the Study:

  • To review methods for controlling bioactive ligand presentation in biomaterials.
  • To explore spatiotemporally varying cues for cell culture.
  • To highlight potential genetically encoded, light-activated approaches for dynamic material bioactivity regulation.

Main Methods:

  • Review of existing literature on dynamic control of cell-material interactions.
  • Analysis of various mechanisms for presenting spatiotemporally varying biochemical cues.
  • Discussion of genetically encoded strategies for light-controlled bioactivity.

Main Results:

  • Several mechanisms exist for controlling bioactive ligand presentation in biomaterials.
  • Dynamic control over cell-material interactions aims to mimic the extracellular matrix's role in cell signaling.
  • Genetically encoded, light-activated methods offer future potential for dynamic regulation.

Conclusions:

  • Effective control over the cell microenvironment's biochemical cues is crucial for regenerative medicine.
  • Current methods focus on dynamic control of ligand presentation in biomaterials.
  • Future research directions include light-inducible genetic systems for precise control over material bioactivity.