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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

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The future of chronic lymphocytic leukemia: potential directions from ASH 2017

Stefano Molica1

  • 1a Department Hematology-Oncology , Azienda Ospedaliera Pugliese-Ciaccio , Catanzaro , Italy.

Expert Review of Hematology
|May 24, 2018
PubMed
Abstract

Insights

Novel targeted therapies are revolutionizing chronic lymphocytic leukemia (CLL) treatment. Combining these novel agents (NAs) presents challenges, but offers hope for curative strategies.

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Novel targeted therapies like ibrutinib, venetoclax, and idelalisib have transformed chronic lymphocytic leukemia (CLL) treatment.
  • Developing effective combinations of novel agents (NAs) with distinct mechanisms and non-overlapping toxicities is complex.

Purpose of the Study:

  • To review novel combination strategies for CLL presented at the 2017 American Society Hematology Annual Meeting.
  • To evaluate the efficacy of novel agents in combination with other treatments for CLL.

Main Methods:

  • Review of clinical trials presented at the 2017 American Society Hematology Annual Meeting.
  • Analysis of combination regimens including NA plus anti-CD20 monoclonal antibody, NA plus NA, and NA plus chemo-immunotherapy.

Main Results:

  • Several trials combining novel agents (NAs) were presented, exploring various therapeutic combinations.
  • Ongoing studies are evaluating the efficacy of these novel combinations in CLL patients.

Conclusions:

  • Developing well-tolerated, highly effective combination strategies with curative potential for CLL is an emerging realistic goal.
  • Sequencing of novel agents (NAs) remains a reasonable approach until more mature combination study results are available.
Keywords:
ASH 2017CLLcombination novel agentsibrutinibvenetoclax

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