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Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
Published on: September 29, 2017
Chitosan Hydrogels and Bionanocomposites Formed through the Mineralization and Regulated Charging
Irina Postnova1,2, Vladimir Silant'ev1, Sergei Sarin1
1Institute of Chemistry, Far East Department, Russian Academy of Sciences, Vladivostok, 690022, Russia.
Abstract:
The account presents survey of our systematic studies on chitosan. Only this polysaccharide bears cationic charges, possesses antimicrobial activity and wound healing ability that make it highly appropriate for using in medicine, biomedical engineering, cosmetics, food, packaging. However, its application meets with severe limitation. Chitosan belongs to polysaccharides that do not jellify solutions. Main approaches are based on the chemical modifications and cross-linking, but these treatments impairs therewith the biocompatibility and biological activity of chitosan. We have developed approaches in which monolithic hydrogels are fabricated via the mineralization of polysaccharide by method of green sol-gel chemistry and via the formation of polyelectrolyte complex with oppositely charged counterparts in the regime of its charging by means of regulated acidification. The latter approach was also extended for the preparation of chitosan bionanocomposites and films with nanoparticles.
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