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Related Concept Videos

Aromatic Compounds: Overview01:25

Aromatic Compounds: Overview

14.3K
In general, the term ‘aromatic’ indicates a pleasant smell or fragrance from fresh flowers, freshly prepared coffee, etc. In the early history of organic chemistry, many benzene derivatives were isolated from the pleasant odor oils of the plants. For example, vanillin was isolated from the oil of vanilla, methyl salicylate from the oil of wintergreen, and cinnamaldehyde from the oil of cinnamon. They all had a pleasant odor; hence the name aromatic was given.
In 1825, Faraday isolated...
14.3K
NMR Spectroscopy of Aromatic Compounds01:14

NMR Spectroscopy of Aromatic Compounds

6.4K
Aromatic compounds can be identified or analyzed using proton NMR and carbon‐13 NMR. Typically, aromatic hydrogens or hydrogens directly bonded to the aromatic rings are strongly deshielded by the aromatic ring current. Therefore, they absorb in the range of 6.5–8.0 ppm in proton NMR spectra. For instance, aromatic hydrogens directly bonded to the benzene ring absorb at 7.3 ppm. However, aromatic hydrogens of larger rings absorb farther upfield or downfield than the ideal range.
6.4K
Nomenclature of Aromatic Compounds with a Single Substituent01:23

Nomenclature of Aromatic Compounds with a Single Substituent

10.4K
Benzene is the simplest aromatic hydrocarbon or arene. The IUPAC names for simple monosubstituted benzene derivatives are derived by adding the substituent's name as a prefix to the parent benzene. For example, halobenzene, where the halogen could be fluoro (F), chloro (Cl), bromo (Br), and iodo (I).
10.4K
Five-Membered Heterocyclic Aromatic Compounds: Overview01:13

Five-Membered Heterocyclic Aromatic Compounds: Overview

5.5K
Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom,...
5.5K
Nomenclature of Aromatic Compounds with Multiple Substituents01:11

Nomenclature of Aromatic Compounds with Multiple Substituents

10.6K
When more than one substituent is present on the benzene ring, the IUPAC nomenclature depends on the number of substituents present.
For disubstituted benzene derivatives, with two groups attached to the benzene ring, three constitutional isomers are possible. For example, consider dimethyl benzene, often called xylene, where the second methyl group can be substituted at the second, third, or fourth carbon. The relative position of the substituents is represented by prefixes ortho, meta, or...
10.6K
Mass Spectrometry: Aromatic Compound Fragmentation01:23

Mass Spectrometry: Aromatic Compound Fragmentation

2.5K
Upon ionization, aromatic compounds generate a molecular ion that is observed as a prominent peak in their mass spectra. For example, the molecular ion peak for benzene appears at a mass-to-charge ratio of 78, while toluene is observed at a mass-to-charge ratio of 92. The molecular ion benzene is highly stable and does not readily undergo further fragmentation due to the significant amount of energy required to disrupt the aromatic stability of the benzene ring. In contrast, the molecular ion...
2.5K

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Related Experiment Video

Updated: Feb 10, 2026

Generation of Alginate Microspheres for Biomedical Applications
10:33

Generation of Alginate Microspheres for Biomedical Applications

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Biomedical Applications of Aromatic Azo Compounds.

Yousaf Ali1,2, Shafida Abd Hamid1, Umer Rashid3

  • 1Kulliyyah of Science, International Islamic University Malaysia, Bandar Indera Mahkota, 25200 Kuantan, Malaysia.

Mini Reviews in Medicinal Chemistry
|May 25, 2018
PubMed
Summary

Azo compounds, known for coloring, show potential in medicine, particularly for cancer therapy and diagnosis. Despite early concerns about mutagenesis, current research explores their biomedical applications.

Keywords:
Azo compoundsAzo dyesantimicrobialantiviralcancerdrug delivery.

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Area of Science:

  • Medicinal Chemistry
  • Biomedical Science
  • Organic Chemistry

Background:

  • Azo compounds are extensively utilized in various industries, including textiles and cosmetics.
  • Beyond coloration, azo compounds exhibit antimicrobial, antiviral, antifungal, and cytotoxic properties.
  • They also function as drug carriers and in cellular staining.

Purpose of the Study:

  • To review the medical applications of azo compounds, with a focus on cancer research.
  • To highlight the potential of azo compounds in cancer diagnosis and therapy.
  • To briefly discuss the biomedical significance and negative implications of azo compounds.

Main Methods:

  • Literature review of existing research on azo compounds and their biological activities.
  • Analysis of studies investigating azo compounds in cancer diagnosis and chemotherapy.
  • Examination of the role of cis-trans interchange in azo compound activity.

Main Results:

  • Azo compounds possess diverse biological activities, including potential therapeutic and diagnostic uses in oncology.
  • Their application in drug delivery systems, such as colon-targeted delivery, is being explored.
  • Despite historical concerns regarding carcinogenicity, ongoing research is screening aromatic azo compounds for biomedical potential.

Conclusions:

  • Azo compounds hold promise for advancements in cancer diagnosis and therapy.
  • Further research is needed to fully elucidate their biomedical significance and mitigate potential risks.
  • The dual nature of azo compounds, with both beneficial and detrimental implications, requires careful consideration in their application.