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Updated: Feb 10, 2026

Non-invasive Imaging of Disseminated Candidiasis in Zebrafish Larvae
Published on: July 30, 2012
Use of T2MR in invasive candidiasis with and without candidemia
Ioannis M Zacharioudakis1,2, Fainareti N Zervou1,2, Eleftherios Mylonakis1
1Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Abstract:
The mortality associated with invasive candidiasis remains unacceptably high. The T2 magnetic resonance (T2MR) assay is a novel US FDA-approved molecular diagnostic assay for the diagnosis of candidemia that can rapidly detect the five most commonly isolated Candida spp. In clinical trials, T2MR has exhibited good clinical sensitivity and specificity. Potential benefits from the adoption of T2MR technology in the diagnostic and therapeutic algorithms for invasive candidiasis can arise from timely diagnosis of disease, increased case detection, tailored therapy and decrease in empiric antifungal treatment. As everyday clinical experience with the assay is evolving, we discuss the utility of T2MR in invasive candidiasis with and without candidemia based on the currently available evidence regarding its performance.
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