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Enprostil inhibits post-prandial gastrin release: a dose-response study
S Lanzon-Miller1, M C Allison, R E Pounder
1Academic Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Alimentary Pharmacology & Therapeutics
|August 1, 1988
Summary
Enprostil significantly reduced post-meal gastrin levels in healthy volunteers. Indomethacin, however, increased these gastrin concentrations, highlighting differing effects on gastric hormone release.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Gastrin plays a crucial role in regulating gastric acid secretion.
- Understanding factors that influence post-prandial gastrin release is important for gastrointestinal health.
Purpose of the Study:
- To investigate the effect of enprostil on post-prandial gastrin release.
- To compare the effects of enprostil with indomethacin on gastrin levels.
Main Methods:
- A double-blind, placebo-controlled study was conducted with nine healthy volunteers.
- Subjects received single oral doses of enprostil (8.75–70 µg) or indomethacin (25 mg) before a standard breakfast.
- Plasma gastrin concentrations were measured post-prandially.
Main Results:
- Enprostil demonstrated a significant, dose-related decrease in median post-prandial plasma gastrin (29–44%).
- Indomethacin administration resulted in a significant (38%) increase in median post-prandial plasma gastrin.
Conclusions:
- Enprostil effectively suppresses post-prandial gastrin release in a dose-dependent manner.
- Enprostil and indomethacin exhibit opposing effects on post-prandial gastrin concentrations.