[Method of Permissible Source Region Selection Based on FMT Image and CT Data].

Area of Science:

• Biomedical Imaging
• Medical Physics
• Optical Imaging

Background:

• Fluorescence Molecular Tomography (FMT) enables visualization of biological processes.
• Accurate reconstruction of light sources is crucial for FMT applications.
• Integrating Computed Tomography (CT) data can improve FMT resolution and accuracy.

Purpose of the Study:

• To develop a novel method for selecting permissible source regions in FMT using combined FMT and CT data.
• To enhance the accuracy of inner light source reconstruction in FMT.
• To reduce the ill-posedness associated with inverse problems in FMT.

Main Methods:

• Estimating light source position and depth from FMT images.
• Establishing coordinate correspondence between FMT and CT images.
• Marking light source positions in CT data and generating a mesh for improved reconstruction.

Main Results:

• The proposed method successfully identifies permissible source regions by integrating FMT and CT data.
• Accurate marking of light source positions in CT data was achieved.
• Experimental results demonstrated a reduction in the ill-posedness of the inverse problem.

Conclusions:

• The combined FMT and CT approach offers a robust solution for accurate inner light source reconstruction.
• This method significantly improves the precision of light source localization in FMT.
• The technique holds promise for advancing quantitative molecular imaging applications.