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Glycofunctionalization of Poly(lactic- co-glycolic acid) Polymers: Building Blocks for the Generation of Defined
Alessandro Palmioli1, Barbara La Ferla1
1Department of Biotechnology and Bioscience , University of Milano-Bicocca , Piazza della Scienza 2 , I-20126 Milan , Italy.
Abstract:
A set of poly(lactic- co-glycolic acid) polymers functionalized with different monosaccharides as well as glycodendrimers and surface-decorated nanoparticles (NPs) were synthesized and characterized. The functionalization of the polymer was carried out through amide bond formation with amino-modified sugar monomers and through a biocompatible chemoselective method exploiting the reducing end of a free sugar. The assemblage of the NPs adopting a nanoprecipitation method was straightforward and allowed the preparation of sugars/sugar dendrimer coated NPs.
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