Related Experiment Video
Updated: Feb 10, 2026
06:33
Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
8.1K
PET staging of amyloidosis using striatum
Bernard J Hanseeuw1, Rebecca A Betensky2, Elizabeth C Mormino3
1Department of Radiology, Massachusetts General Hospital, Harvard Medical School, and the Martinos Center for Biomedical Imaging, Charlestown, MA, USA; Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Summary
New Alzheimer's dementia staging using amyloid positron emission tomography (PET) shows that including striatal amyloid deposition improves prediction of cognitive decline over models using only cortical amyloid.
Area of Science:
- Neurology
- Neuroimaging
- Biomarkers
Background:
- Amyloid positron emission tomography (PET) is crucial for Alzheimer's dementia (AD) research, often using binary cortical amyloid measures.
- Not all individuals with high cortical amyloid experience rapid cognitive decline, suggesting limitations in current staging methods.
Purpose of the Study:
- To evaluate a three-stage PET classification model incorporating both cortical and striatal amyloid deposition.
- To determine if this enhanced model better reflects Alzheimer's dementia progression compared to cortical measures alone.
Main Methods:
- Classified PET data from 1433 participants (normal, mild cognitive impairment, AD) into three stages: low cortical; high cortical, low striatal; and high cortical, high striatal amyloid.
- Utilized 3-year follow-up PET data to explore successive amyloid involvement in cortex and striatum.
- Assessed associations between PET stages, hippocampal volumes, and cognitive outcomes.
Main Results:
- Amyloid deposition was observed sequentially, first in the cortex and then in the striatum.
- The three-category staging including striatal amyloid significantly improved prediction of hippocampal volumes and subsequent cognition compared to cortical measures alone.
Conclusions:
- Amyloid PET can track amyloid expansion from the cortex to subcortical regions like the striatum.
- Incorporating striatal amyloid signal as a marker of advanced amyloidosis enhances predictive power in Alzheimer's dementia research.
Related Concept Videos
01:26Stages of Infection
65.4K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.4K
01:22Stages of Sleep
1.5K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.5K
01:22Stages of General Anesthesia
1.8K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
1.8K
01:16Psychosexual Stages of Personality: Oral
3.2K
The oral stage is the initial phase of Sigmund Freud's theory of psychosexual development, occurring from birth to approximately 12 to 18 months. During this period, the infant's mouth serves as the primary source of pleasure, with actions such as sucking, chewing, biting, and drinking playing a crucial role in reducing tension. These activities are essential not only for nourishment but also for the infant's psychological and emotional satisfaction.
Weaning, typically occurring...
Weaning, typically occurring...
3.2K
01:26Psychosexual Stages of Personality: Anal
4.2K
Sigmund Freud's theory of psychosexual development describes the anal stage as occurring between 18 months and three years of age. During this period, children derive pleasure from controlling and releasing their bowel movements. However, they quickly learn that societal expectations impose restrictions on when and where this can happen. This stage marks a critical point where children begin to develop a sense of control and mastery over their bodily functions, as well as their broader...
4.2K
01:12Psychosexual Stages of Personality: Phallic
1.9K
The third stage of psychosexual development proposed by Freud is the phallic stage, occurring between the ages of 3 and 6. During this period, children become aware of their bodies and the differences between males and females. The erogenous zone in this stage is the genitals, and conflicts arise as children develop desires toward the opposite-sex parent. Boys experience the Oedipus complex, where they desire their mother and view their father as a rival. This leads to castration anxiety, the...
1.9K