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The CD44-HA axis and inflammation in atherosclerosis: A temporal perspective

Mia Krolikoski1, James Monslow1, Ellen Puré1

  • 1University of Pennsylvania, 380 S. University Avenue, Philadelphia, PA 19104, United States.

Matrix Biology : Journal of the International Society for Matrix Biology
|May 25, 2018
PubMed

Insights

Cardiovascular disease involves chronic inflammation. This review explores how CD44 and hyaluronic acid (HA) influence inflammatory cells in atherosclerosis, offering potential therapeutic targets for disease management.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Molecular Biology

Background:

  • Cardiovascular disease (CVD) arises from chronic inflammation in atherosclerosis.
  • CD44 receptor is implicated in early stages of atherosclerosis.
  • The role of CD44 in later stages of CVD remains unclear.

Purpose of the Study:

  • To review the role of CD44-dependent and hyaluronic acid (HA)-dependent effects on inflammatory cells in atherosclerosis.
  • To elucidate CD44's function throughout the entire progression of atherosclerosis.
  • To identify the CD44-HA axis as a potential therapeutic target for CVD.

Main Methods:

  • Literature review focusing on CD44 and HA in atherogenesis.
  • Analysis of CD44's impact on inflammatory cell functions.
  • Examination of CD44-HA interactions in cardiovascular disease models.

Main Results:

  • CD44 and HA significantly influence inflammatory cell behavior in atherosclerosis.
  • CD44-mediated inflammation is critical from disease initiation to progression.
  • The CD44-HA axis plays a key role in regulating inflammatory responses in CVD.

Conclusions:

  • Understanding CD44 and HA's role in inflammation is crucial for CVD.
  • The CD44-HA axis presents a promising therapeutic target for halting atherosclerosis.
  • Targeting CD44-HA may facilitate disease regression in cardiovascular disease.

Keywords:
AtherosclerosisCD44HyaluronanInflammation

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