The CD44-HA axis and inflammation in atherosclerosis: A temporal perspective

Area of Science:

• Cardiovascular Science
• Immunology
• Molecular Biology

Background:

• Cardiovascular disease (CVD) arises from chronic inflammation in atherosclerosis.
• CD44 receptor is implicated in early stages of atherosclerosis.
• The role of CD44 in later stages of CVD remains unclear.

Purpose of the Study:

• To review the role of CD44-dependent and hyaluronic acid (HA)-dependent effects on inflammatory cells in atherosclerosis.
• To elucidate CD44's function throughout the entire progression of atherosclerosis.
• To identify the CD44-HA axis as a potential therapeutic target for CVD.

Main Methods:

• Literature review focusing on CD44 and HA in atherogenesis.
• Analysis of CD44's impact on inflammatory cell functions.
• Examination of CD44-HA interactions in cardiovascular disease models.

Main Results:

• CD44 and HA significantly influence inflammatory cell behavior in atherosclerosis.
• CD44-mediated inflammation is critical from disease initiation to progression.
• The CD44-HA axis plays a key role in regulating inflammatory responses in CVD.

Conclusions:

• Understanding CD44 and HA's role in inflammation is crucial for CVD.
• The CD44-HA axis presents a promising therapeutic target for halting atherosclerosis.
• Targeting CD44-HA may facilitate disease regression in cardiovascular disease.