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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care.
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An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care. Here are a few more healthcare professionals.
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Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
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The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
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Personalized Needles for Microinjections in the Rodent Brain
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Personalized therapy: an interdisciplinary challenge.

Elba S Vazquez1

  • 1University of Buenos Aires, Assistant Professor, Assistant Head of Department of Biological Chemistry, School of Science, University of Buenos Aires - Independent Researcher, Argentine National Research Council (CONICET), Ciudad Universitaria, Pabellón II, 4º Piso, Buenos Aires, Argentina. elba@qb.fcen.uba.ar.

Personalized Medicine
|May 26, 2018
PubMed
Summary
This summary is machine-generated.

Integrating genomics, proteomics, and metabolomics provides a comprehensive view of biological processes. This multidisciplinary approach is essential for developing effective, targeted therapeutic strategies.

Keywords:
cytochrome P450metabolomicspersonalized therapypharmacogenomicspolymorphismsproteomicstoxicogenomics

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Systems Biology

Background:

  • Understanding complex diseases requires integrating multiple biological data types.
  • Gene expression (genomics), protein expression (proteomics), and metabolic profiles (metabolomics) offer complementary insights.
  • Current therapeutic strategies often lack a holistic view of molecular pathways.

Purpose of the Study:

  • To propose a multidisciplinary strategy combining genomics, proteomics, and metabolomics.
  • To rationalize therapeutic strategy development by considering multiple molecular layers.
  • To gain insights into disease-related pathways in target and contributory tissues.

Main Methods:

  • Integrating multi-omics data (genomics, proteomics, metabolomics).
  • Analyzing gene, protein, and metabolic profiles within the target organ.
  • Investigating implicated pathways in related tissues.

Main Results:

  • A unified framework for analyzing diverse biological data.
  • Identification of interconnected pathways through integrated analysis.
  • Enhanced understanding of disease mechanisms at multiple molecular levels.

Conclusions:

  • Combining genomics, proteomics, and metabolomics is crucial for rationalizing therapeutic strategies.
  • Multidisciplinary approaches facilitate the translation of findings into novel therapies.
  • Systems-level analysis provides a more comprehensive understanding of biological systems and disease.