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Updated: Feb 10, 2026

Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Cytochrome P450 gene-based drug prescribing and factors impacting translation into routine clinical practice
Russell A Wilke1, A Kenneth Musana2, Wendell W Weber3
1Center for Human Genetics, Marshfield Clinic Research Foundation, Department of Internal Medicine, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, WI 54449, USA. wilke.russell@mcrf.mfldclin.edu.
Abstract:
Pharmacogenetics represents a rapidly advancing, competitive field of investigation. Due to the potential for clinically recognizable interactions between a set of old polymorphic genes and a relatively new environmental insult (drugs), many human geneticists believe that variability in the drug-metabolizing enzyme systems will soon translate into clinical practice across entire populations. Despite this, the field has not yet received widespread clinical acceptance. This article will review the common cytochrome P450 gene polymorphisms and discuss the factors that may facilitate (or attenuate) their translation into clinical practice.
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