Related Experiment Video
Updated: Feb 10, 2026
09:16
Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury
Published on: February 26, 2017
10.2K
Acute lung injury: how to stabilize a broken lung
Gary F Nieman1, Penny Andrews2, Joshua Satalin3
1Department of Surgery, SUNY Upstate Medical University, 750 E. Adams Street, Syracuse, NY, 13210, USA.
Critical Care (London, England)
|May 26, 2018
Summary
Acute Respiratory Distress Syndrome (ARDS) causes lung injury. A novel mechanical breathing strategy may stabilize the lung, preventing further ventilator-induced lung injury (VILI) and reducing ARDS incidence.
Area of Science:
- Pulmonary Medicine
- Critical Care
- Mechanical Ventilation
Background:
- Acute Respiratory Distress Syndrome (ARDS) involves lung collapse, airway edema, and unstable alveoli.
- These conditions lead to altered alveolar mechanics and susceptibility to ventilator-induced lung injury (VILI).
Purpose of the Study:
- To propose a mechanical ventilation strategy to stabilize the acutely injured lung.
- To investigate the potential of preventing VILI and reducing ARDS incidence.
Main Methods:
- Conceptual framework based on lung recruitment and stabilization.
- Analogy to casting a broken bone for healing.
Main Results:
- Hypothesized that mechanical breaths can "cast" the injured lung.
- Proposed that this approach can prevent VILI.
Conclusions:
- A mechanical breathing strategy could stabilize ARDS lungs.
- This approach may significantly reduce VILI and ARDS incidence.
Related Concept Videos
01:47Lung Capacity
56.4K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
01:13Pleura of the Lungs
7.5K
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
7.5K
01:17Gross Anatomy of the Lungs
4.8K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
4.8K
01:22Acute Kidney Injury I: Introduction
786
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
786
01:29Acute Kidney Injury II: Pathophysiology
1.1K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.1K
01:22Acute Kidney Injury VI: Nursing Management
485
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
485