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Related Experiment Video

Updated: Feb 10, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
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Cooling the Itch via TRPM8.

Boyi Liu1, Sven-Eric Jordt2

  • 1Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China; Department of Anesthesiology, Duke University School of Medicine, Durham, North Carolina, USA.

The Journal of Investigative Dermatology
|May 26, 2018
PubMed
Summary

Cooling and menthol effectively relieve itch by activating the TRPM8 ion channel. Further research into TRPM8 activation could lead to new itch relief treatments.

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Area of Science:

  • Dermatology
  • Neuroscience
  • Molecular Biology

Background:

  • Cooling and menthol are known temporary remedies for itch relief.
  • Various conditions like insect bites, psoriasis, and atopic dermatitis cause significant pruritus.
  • The sensory mechanisms underlying itch relief are not fully understood.

Purpose of the Study:

  • To investigate the role of the TRPM8 ion channel in itch relief mediated by cooling.
  • To explore the potential of TRPM8 as a therapeutic target for pruritus.

Main Methods:

  • Utilized animal models to study itch responses.
  • Investigated the involvement of the TRPM8 channel in cooling-induced itch suppression.

Main Results:

  • Demonstrated that the TRPM8 ion channel is essential for cooling to alleviate itch.
  • Showcased the direct link between TRPM8 activation and itch relief.

Conclusions:

  • TRPM8 (transient receptor potential melastatin 8) is a key mediator of cooling-induced itch relief.
  • Pharmacological activation of TRPM8 presents a promising strategy for developing novel antipruritic therapies.