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Updated: Feb 10, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Report of a man with heterotopic ossification of the legs
Mónica García-Arpa1, Miguel A Flores-Terry1, Monserrat Franco-Muñoz1
1Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
Abstract:
Heterotopic ossification is an uncommon disorder that consists of deposition of ectopic bone outside the extraskeletal tissues. In the skin, it can be primary, in association with genetic syndromes, or be secondary to different disorders. The latter include subcutaneous ossification of the legs in chronic venousinsufficiency, an infrequent and unrecognized complication. We report the case of a patient with subcutaneous ossification of both legs secondary to venous insufficiency and review the literature.
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