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18F-choline PET/MRI in suspected recurrence of prostate carcinoma

C Riola-Parada1, J L Carreras-Delgado2, V Pérez-Dueñas3

  • 1Servicio de Medicina Nuclear, Hospital Universitario HM Puerta del Sur, Móstoles, Madrid, España.

Revista Espanola De Medicina Nuclear E Imagen Molecular
|May 26, 2018
PubMed
Abstract

Insights

Simultaneous 18F-choline PET/MRI shows a considerable detection rate for prostate cancer recurrence, even with low PSA levels. This imaging technique

Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Prostate cancer recurrence detection is crucial for effective management.
  • Accurate staging of recurrent prostate cancer impacts treatment decisions.
  • Novel imaging techniques are needed to improve detection rates.

Purpose of the Study:

  • To assess the utility of 18F-choline PET/MRI in diagnosing prostate cancer recurrence.
  • To correlate the detection rate of 18F-choline PET/MRI with PSA levels and Gleason scores.

Main Methods:

  • 27 patients with suspected prostate cancer recurrence underwent 18F-choline PET/MRI.
  • Findings were validated using pathological analysis, other imaging, or treatment response.
  • Patient data included PSA levels and Gleason scores at diagnosis.

Main Results:

  • 18F-choline PET/MRI detected recurrence in 15 out of 27 patients (55.56% detection rate).
  • Identified recurrences included local (15%), lymph node metastases (18%), and bone metastases (26%).
  • No statistically significant correlation was found between detection rates and PSA levels or Gleason scores.

Conclusions:

  • 18F-Fcholine PET/MRI demonstrates a notable detection rate for prostate cancer recurrence.
  • The technique is valuable even in cases with relatively low prostate-specific antigen (PSA) values.
  • Gleason score and PSA levels did not significantly influence the detection capability of 18F-choline PET/MRI in this cohort.
Keywords:
CholineColinaCáncer de próstataPET/MRIPET/RMProstate cancerRecurrenceRecurrencia

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