Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Metabolism?00:52

What is Metabolism?

132.1K
Overview
132.1K
Physical and Chemical Properties of Matter02:57

Physical and Chemical Properties of Matter

166.9K
The characteristics that enable us to distinguish one substance from another are called properties.
166.9K
Physical Pendulum01:06

Physical Pendulum

2.8K
When a rigid body is hanging freely from a fixed pivot point and is displaced, it oscillates similar to a simple pendulum and is known as a physical pendulum. The period and angular frequency of a physical pendulum are obtained by using the small-angle approximation and drawing parallels with a spring-mass system. The small-angle approximation (sinθ=θ) is valid up to about 14°.
When dealing with complicated systems, the mass moment of inertia is an important parameter, as it...
2.8K
The Scope of Physics01:17

The Scope of Physics

53.4K
Physics is concerned with the interactions of energy, matter, space, and time, in order to discover the underlying mechanisms that underpin all phenomena. The word "physics" comes from the Greek word "phúsis", which means nature. Physics seeks to comprehend the natural world around us at its most fundamental level. It emphasizes the use of quantitative laws to do this, which could be valuable in other fields that want to push the performance boundaries of present...
53.4K
Solving Problems in Physics02:32

Solving Problems in Physics

8.9K
Problem-solving is the ability to apply general physical principles to specific situations, usually expressed by equations. It is an essential skill in physics, and can also be useful for applying physics in everyday life as well. Analytical skills and problem-solving abilities can be applied to new situations, compared to a list of facts, which can never be extensive enough to include every possible circumstance. To solve physics problems, a certain amount of creativity and insight is...
8.9K
Estimation of the Physical Quantities01:05

Estimation of the Physical Quantities

7.9K
On many occasions, physicists, other scientists, and engineers need to make estimates of a particular quantity. These are sometimes referred to as guesstimates, order-of-magnitude approximations, back-of-the-envelope calculations, or Fermi calculations. The physicist Enrico Fermi was famous for his ability to estimate various kinds of data with surprising precision. Estimating does not mean guessing a number or a formula at random. Instead, estimation means using prior experience and sound...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A quantitative approach for defining the degradability landscape of protein degraders.

Nature communications·2026
Same author

Shape factor analysis as a quantitative framework for assessing spheroid and organoid morphology and invasiveness.

APL bioengineering·2026
Same author

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

The Journal of experimental medicine·2026
Same author

Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss.

bioRxiv : the preprint server for biology·2026
Same author

Dynamic visualization of physiological CaMKII activity using sensitive FRET biosensors.

bioRxiv : the preprint server for biology·2026
Same author

Very low-carbohydrate ketogenic diet in treatment-naïve women with endometrial cancer and overweight: a randomized feasibility study.

Nature communications·2026

Related Experiment Video

Updated: Feb 10, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

11.0K

Cancer metabolism gets physical.

Peter DelNero1, Benjamin D Hopkins2, Lewis C Cantley2

  • 1Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.

Science Translational Medicine
|May 26, 2018
PubMed
Summary

Patient-derived culture models assess drug sensitivity but lack fidelity. Engineered systems mimicking the physical microenvironment can improve predictive power for precision medicine.

More Related Videos

Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts
10:51

Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts

Published on: August 23, 2017

12.9K
Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption
08:45

Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption

Published on: June 20, 2025

598

Related Experiment Videos

Last Updated: Feb 10, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

11.0K
Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts
10:51

Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts

Published on: August 23, 2017

12.9K
Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption
08:45

Assessment of Physical Activity Intensity with Accelerometers and Oxygen Consumption

Published on: June 20, 2025

598

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Pharmacology

Background:

  • Patient-derived culture models are crucial for evaluating drug sensitivity and linking genomic data to personalized therapies.
  • Current models exhibit limitations in clinical translation due to insufficient fidelity.

Purpose of the Study:

  • To explore the role of the physical microenvironment in regulating cellular metabolism.
  • To propose engineered culture systems for enhancing the predictive accuracy of precision medicine.

Main Methods:

  • Reviewing literature on physical microenvironment influences on cell metabolism.
  • Describing the design principles of engineered culture systems.

Main Results:

  • The physical microenvironment significantly impacts cell metabolism.
  • Engineered culture systems offer a pathway to improve the fidelity of patient-derived models.

Conclusions:

  • Understanding microenvironmental regulation of metabolism is key to improving preclinical models.
  • Advanced engineered culture systems hold promise for advancing precision medicine through more predictive drug sensitivity assessments.