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Reperfusion Injury after ischemic Stroke Study (RISKS): single-centre (Florence, Italy), prospective observational
Benedetta Piccardi1,2, Francesco Arba1, Mascia Nesi1
1Stroke Unit, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
BMJ Open
|May 26, 2018
Summary
Reperfusion injury after ischemic stroke can be worsened by blood-brain barrier disruption and biomarkers. This study assesses imaging and biomarker effects on stroke recovery.
Area of Science:
- Neuroscience
- Biomedical Imaging
- Biomarker Discovery
Background:
- Ischemic stroke treatments aimed at restoring blood flow can paradoxically cause reperfusion injury.
- Blood-brain barrier (BBB) disruption and circulating biomarkers are implicated in reperfusion injury.
- Understanding these factors is crucial for improving stroke outcomes.
Purpose of the Study:
- To evaluate the relative impact of imaging-assessed BBB disruption and circulating biomarkers on reperfusion injury.
- To determine the combined effect of BBB integrity and biomarkers on clinical outcomes 3 months post-stroke.
- To identify predictive markers for reperfusion injury in ischemic stroke patients.
Main Methods:
- An observational study including 140 ischemic stroke patients treated with reperfusion therapies.
- Assessment of BBB disruption using CT perfusion (CTP) before treatment.
- Measurement of a wide panel of biomarkers before intervention and 24 hours post-intervention.
Main Results:
- Reperfusion injury will be defined by radiological signs of hemorrhagic transformation at 24 hours.
- Clinical status will be assessed at 3 months post-stroke.
- The study will analyze the independent and combined effects of BBB status and biomarkers on outcomes.
Conclusions:
- Findings will elucidate the roles of BBB disruption and biomarkers in stroke reperfusion injury.
- This research aims to refine risk stratification and treatment strategies for ischemic stroke.
- Identifying key predictors may lead to targeted interventions to mitigate reperfusion injury and improve patient recovery.
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