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Hematocrit Measurement with R2* and Quantitative Susceptibility Mapping in Postmortem Brain.

A J Walsh1,2, H Sun1, D J Emery2

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Summary
This summary is machine-generated.

Quantitative susceptibility mapping (QSM) and R2* mapping show strong correlation for measuring venous oxygenation in postmortem subjects. This supports QSM for in vivo venous oxygenation and hematocrit assessment.

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiology

Background:

  • Noninvasive venous oxygenation quantification via MR imaging is crucial for understanding neurological diseases.
  • Existing MR methods face limitations due to flow sensitivity and hematocrit assumptions.
  • Postmortem imaging offers a flow-artifact-free environment for method evaluation and hematocrit calculation.

Purpose of the Study:

  • To compare two venous oxygenation quantification methods: transverse relaxation (R2*) mapping and quantitative susceptibility mapping (QSM).
  • To evaluate these methods in an in situ postmortem setting.
  • To assess the correlation between R2* and QSM for venous oxygenation and hematocrit determination.

Main Methods:

  • Performed transverse relaxation (R2*) mapping and quantitative susceptibility mapping (QSM) on a 4.7T MR imaging system.
  • Acquired intravenous measurements in major draining intracranial veins of 3 postmortem subjects.
  • Applied QSM to 10 healthy control subjects for comparison with reference venous oxygenation values.

Main Results:

  • R2* mapping and QSM demonstrated a significant and strong correlation in early postmortem subjects (R² = 0.805–0.836).
  • Consistently higher R2* and susceptibility values were observed in gravitationally dependent venous segments.
  • Observed hematocrit values ranged from 0.102 to 0.580, with R2* and susceptibility reaching up to 291 s⁻¹ and 1.75 ppm, respectively.

Conclusions:

  • R2* mapping and QSM show a high correlation for measuring venous oxygenation in large intracranial draining veins of early postmortem subjects.
  • This study validates the use of QSM for evaluating in vivo venous oxygenation.
  • QSM is also supported for postmortem hematocrit concentration assessment.