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A Novel In Vitro Model of Blast Traumatic Brain Injury
08:59

A Novel In Vitro Model of Blast Traumatic Brain Injury

Published on: December 21, 2018

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Prevalence of Cerebral Microhemorrhage following Chronic Blast-Related Mild Traumatic Brain Injury in Military

E Lotan1,2, C Morley1,3, J Newman3

  • 1From the Departments of Radiology (E.L., C.M., Y.W.L.).

AJNR. American Journal of Neuroradiology
|May 26, 2018
PubMed
Abstract

Insights

No cerebral microhemorrhages were found in military service members with chronic blast-related mild traumatic brain injury. This suggests differences in injury mechanisms compared to blunt head trauma, impacting microhemorrhage detection.

Area of Science:

  • Neuroscience
  • Radiology
  • Military Medicine

Background:

  • Cerebral microhemorrhages (CMH) are markers of mild traumatic brain injury (mTBI).
  • Blast-related mTBI may have different injury mechanisms than blunt head trauma.
  • Previous studies suggest lower CMH prevalence in military populations with mixed TBI types.

Purpose of the Study:

  • To determine the prevalence of CMH in military service members with chronic blast-related mTBI.
  • To investigate potential differences in CMH occurrence between blast and blunt TBI mechanisms.

Main Methods:

  • Prospective recruitment of 146 veterans with remote blast-related mTBI.
  • 3T MRI scans were performed.
  • Susceptibility-weighted images were independently assessed for CMH by two neuroradiologists.

Main Results:

  • No cerebral microhemorrhages were detected in any of the 146 participants.
  • This contrasts with civilian studies reporting up to 28% CMH prevalence in blunt TBI.
  • Participants had chronic blast-related mTBI (mean 9.4 years post-injury).

Conclusions:

  • The absence of CMH in this cohort may indicate distinct pathophysiology between blast and blunt TBI.
  • The chronicity of the injury could influence the detectability of CMH.
  • Further research is needed to understand blast TBI mechanisms and long-term effects.

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