Tumor-on-a-chip platforms for assessing nanoparticle-based cancer therapy
Yimin Wang1,2,3, Fabio Cuzzucoli1,2,3,4, Andres Escobar1,2,3,4
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, People's Republic of China.
Nanotechnology
|May 26, 2018
Summary
Nanoparticles (NPs) offer promising cancer therapy options. Novel tumor-on-a-chip platforms improve the evaluation of NP-based cancer treatments, aiding clinical translation.
Area of Science:
- Biomedical Engineering
- Nanomedicine
- Oncology
Background:
- Cancer poses a significant global health and economic challenge.
- Conventional cancer models have limitations in predicting treatment efficacy.
- Nanoparticles (NPs) are crucial in nanomedicine for enhancing cancer therapy.
Purpose of the Study:
- To review cancer models for evaluating NP-based therapy.
- To present advances in tumor-on-a-chip platforms.
- To explore facilitating clinical translation of NP-based cancer therapies.
Main Methods:
- Review of existing literature on cancer models.
- Analysis of novel tumor-on-a-chip platforms.
- Discussion of biomedical engineering approaches.
Main Results:
- Conventional models have predictive limitations.
- Biomimetic tumor-on-a-chip platforms offer improved evaluation.
- These platforms show potential for clinical translation.
Conclusions:
- Tumor-on-a-chip platforms represent a significant advancement.
- These platforms can overcome limitations of current cancer models.
- They are key to advancing NP-based cancer therapy and clinical application.
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