Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

6.5K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.5K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

5.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.0K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.6K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.6K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

5.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.7K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.7K
Health Literacy01:21

Health Literacy

5.4K
Health literacy is an individual's or a community's capacity to comprehend, receive, read, and use relevant healthcare information and services. The World Health Organization (WHO, 2018) defines health literacy as the cognitive and social skills that determine the ability of individuals to gain access to, understand, and use information in ways that promote and maintain good health. As a result, the WHO helps individuals manage long-term health concerns, participate in preventative...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Percent Time Below Range Is Strongly Associated with Clinically Important Level 2 Hypoglycemia Events in Individuals with Type 1 Diabetes.

Diabetes technology & therapeutics·2026
Same author

Adjunctive Treatment with GLP-1 and Dual GLP-1/GIP Receptor Agonists for People with Type 1 Diabetes: Consensus Report and Practical Guidelines for Safe Use.

Diabetes technology & therapeutics·2026
Same author

A longitudinal imaging study of the effects of type 2 diabetes and microvascular disease on diabetic bone disease.

Bone·2026
Same author

Management of Pregnancy in Type 1 Diabetes Using a Novel Automated Insulin Delivery System.

Journal of diabetes science and technology·2026
Same author

The association between 10-year cardiovascular risk and fracture incidence in postmenopausal women: a prospective analysis from the Women's Health Initiative.

Lancet regional health. Americas·2026
Same author

How Continuous Glucose Monitoring Reports Inform Clinical Decision-Making for Older Adults With Type 2 Diabetes: Mapping Clinical Workflow to Situation Awareness.

Journal of diabetes science and technology·2026

Related Experiment Video

Updated: Feb 10, 2026

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

5.9K

Bone health in type 1 diabetes.

Viral N Shah1, R Dana Carpenter2, Virginia L Ferguson3

  • 1Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO.

Current Opinion in Endocrinology, Diabetes, and Obesity
|May 26, 2018
PubMed
Summary

Type 1 diabetes (T1D) significantly increases fracture risk, impacting bone structure and quality beyond bone mineral density (BMD). Further research is needed for effective fracture prevention strategies in T1D patients.

More Related Videos

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.3K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Related Experiment Videos

Last Updated: Feb 10, 2026

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

5.9K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.3K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Diseases

Background:

  • Type 1 diabetes (T1D) is a chronic condition affecting bone health.
  • Existing research indicates a link between T1D and increased fracture risk.

Purpose of the Study:

  • To review current literature on T1D's effects on bone.
  • To examine fracture risk, bone mineral density (BMD), structure, and quality in T1D.
  • To explore potential fracture prevention strategies for T1D patients.

Main Methods:

  • Literature review of recent publications.
  • Analysis of studies on T1D's impact on bone parameters.
  • Synthesis of findings on fracture risk and bone quality.

Main Results:

  • T1D is linked to significantly higher fracture risk and lower femoral neck BMD.
  • Bone mineral density alone does not fully explain the elevated fracture risk.
  • T1D alters bone macro- and microstructure, with deficits exacerbated by microvascular complications.

Conclusions:

  • Bone fragility in T1D involves microstructural and tissue-level changes.
  • Advanced glycation endproducts and altered bone turnover contribute to T1D bone fragility.
  • More research is required for improved screening and treatment of osteoporosis in T1D.