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Updated: Feb 10, 2026
07:55
Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
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Herpes zoster ophthalmicus: acute keratitis
1University of California, Davis, UC Davis Eye Center Sacramento, California, USA.
Current Opinion in Ophthalmology
|May 26, 2018
Summary
Herpes zoster ophthalmicus (HZO) can cause acute keratitis, potentially leading to vision loss. Early diagnosis, antiviral treatments, and vaccination are crucial for managing and preventing this ocular complication.
Area of Science:
- Ophthalmology
- Virology
- Infectious Diseases
Background:
- Herpes zoster ophthalmicus (HZO) is a common condition involving the trigeminal nerve.
- Acute keratitis is a frequent ocular complication of HZO.
- The incidence of herpes zoster is increasing, with a trend toward younger patients.
Purpose of the Study:
- To review the findings associated with acute zoster keratitis.
- To outline the management strategies for acute zoster keratitis.
Main Methods:
- Literature review of recent findings and management strategies for acute zoster keratitis.
- Discussion of evolving understanding of corneal involvement in HZO.
- Highlighting new therapeutic options.
Main Results:
- Corneal involvement in HZO is increasingly understood, with new imaging showing viral particles.
- Topical ganciclovir offers a new option for managing HZO-related keratitis unresponsive to oral antivirals.
- The incidence of herpes zoster and HZO is rising, with a declining average patient age.
Conclusions:
- Acute zoster keratitis poses a risk of permanent vision loss.
- Early diagnosis and prompt management are essential to prevent severe complications.
- Antiviral medications and herpes zoster vaccination are key for treatment and prevention, though further research on treatment standards is needed.
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