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Prevention of recurrent venous thrombosis and post-thrombotic syndrome

Gianni Belcaro1, Mark Dugall2, Shu Hu2

  • 1Irvine3 Labs, Circulation Sciences and The Nicolaides' Lab, Dipartimento Sc Med OR BIOTEC, CH-PE University, IA-PSS, Pescara, Italy - cardres@abol.it.

Minerva Cardioangiologica
|May 26, 2018
PubMed

Insights

Pycnogenol® significantly reduced recurrent deep venous thrombosis (R-DVT) and post-thrombotic syndrome (PTS) compared to standard management and aspirin. This study highlights Pycnogenol® as a safe and effective option for managing DVT complications.

Area of Science:

  • Vascular Medicine
  • Pharmacology
  • Thrombosis Research

Background:

  • Post-thrombotic syndrome (PTS) and recurrent deep venous thrombosis (R-DVT) are significant complications following proximal deep vein thrombosis (DVT).
  • Standard management (SM) protocols aim to mitigate these risks, but further therapeutic options are being investigated.

Purpose of the Study:

  • To evaluate the efficacy of different antithrombotic agents in preventing PTS and R-DVT after proximal DVT.
  • To compare Pycnogenol®, ticlopidine, sulodexide, and aspirin against standard management in a post-anticoagulant setting.

Main Methods:

  • A retrospective registry study involving patients who completed anticoagulant therapy for proximal DVT.
  • Comparable groups were assigned to standard management (SM), aspirin (100 mg/day), Pycnogenol® (200 mg/day), ticlopidine (250 mg/day), or sulodexide (500 ULS/day).

Main Results:

  • Pycnogenol® demonstrated the lowest incidence of R-DVT (5.8%) and PTS (6.5%), significantly outperforming SM and aspirin (P<0.05).
  • Aspirin showed a significant reduction in R-DVT and PTS compared to SM (P<0.05).
  • Ticlopidine and sulodexide also exhibited significant reductions in R-DVT and/or PTS compared to SM (P<0.05).

Conclusions:

  • Pycnogenol® is the most effective and safe agent for reducing R-DVT and particularly PTS.
  • Aspirin is effective in reducing PTS and R-DVT for patients who tolerate it.
  • Ticlopidine and sulodexide are also effective antithrombotic strategies in this patient population.
Abstract

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