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Updated: Feb 10, 2026

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Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
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Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2018
1Mayo Clinic, SW Division of Hematology, 200 First Street, Rochester, MN, 55905, USA. gertz.morie@mayo.edu.
Blood Cancer Journal
|May 26, 2018
Summary
Immunoglobulin light chain amyloidosis (AL) requires prompt cancer care provider consideration for symptoms like nephrotic proteinuria and heart failure. Early recognition in smoldering myeloma and MGUS patients prevents diagnostic delays and improves outcomes.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Immunoglobulin light chain amyloidosis (AL) is a plasma cell disorder that can affect multiple organs.
- Patients with monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma are at increased risk.
- Delayed diagnosis of AL amyloidosis can lead to significant morbidity and mortality.
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