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Association between obstructive sleep apnea and erectile dysfunction: a systematic review and meta-analysis.
S V Kellesarian1,2, V R Malignaggi3, C Feng4
1Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA. sergio_kellesarian@urmc.rochester.edu.
International Journal of Impotence Research
|May 26, 2018
Summary
Obstructive sleep apnea (OSA) is linked to a higher risk of erectile dysfunction (ED). Patients without OSA have a significantly lower risk of developing ED, highlighting a crucial connection.
Area of Science:
- Urology
- Sleep Medicine
- Cardiology
Background:
- Erectile dysfunction (ED) is a common condition affecting men's health.
- Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder.
- The relationship between OSA and ED requires further investigation.
Purpose of the Study:
- To systematically review and meta-analyze the association between obstructive sleep apnea (OSA) and erectile dysfunction (ED).
- To answer the focused question: Is there an association between OSA and ED?
Main Methods:
- Systematic review and meta-analysis of indexed databases up to May 2017.
- Inclusion of 28 observational studies (19 cross-sectional, 7 case-control, 2 cohort).
- Exclusion of review articles, case reports, commentaries, and studies on treatment efficacy.
Main Results:
- Qualitative synthesis of 28 observational studies.
- Meta-analysis of 10 studies yielded a combined odds ratio (OR) of 0.45 (95% CI: 0.18-0.71).
- Results indicate a significantly lower risk of ED in patients without OSA compared to those with OSA.
Conclusions:
- Available evidence demonstrates a significant association between OSA and an increased risk of ED.
- Further well-designed controlled clinical trials and longitudinal prospective studies are necessary to confirm these findings.
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