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Dietary sodium butyrate improves intestinal development and function by modulating the microbial community in

Wei Wu1, Zhibin Xiao1, Wenyi An1

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Dietary sodium butyrate (SB) supplementation improved broiler intestinal structure and function, enhancing goblet cells and villus height. SB modulated gut microbiota, with higher doses optimizing gut health.

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Area of Science:

  • Animal Science
  • Nutritional Physiology
  • Gut Health

Background:

  • Poultry production relies on optimal gut health for growth and efficiency.
  • Dietary strategies are explored to enhance intestinal development and function in broilers.
  • Sodium butyrate (SB) is a short-chain fatty acid with potential gut-modulating properties.

Purpose of the Study:

  • To evaluate the impact of coated sodium butyrate (SB) on broiler growth, intestinal morphology, and gut microbiota.
  • To compare SB supplementation with antibiotic treatment in broiler diets.
  • To determine optimal SB dosage for improved intestinal health and function.

Main Methods:

  • A 42-day growth trial involving 720 Arbor Acres male broilers.
  • Six treatment groups: basal diet (control), five SB supplementation levels (200-1000 mg/kg), and an antibiotic group.
  • Analysis included growth performance, intestinal morphology (scanning electron microscopy), antioxidant capacity, gut metabolites, and microbial community composition (16S rRNA sequencing).

Main Results:

  • SB supplementation improved intestinal structure, increasing goblet cells and villus height, with fewer erosions.
  • Higher SB doses (800 mg/kg) enhanced antioxidant capacity and reduced malondialdehyde (MDA) in the jejunum.
  • SB modulated gut microbiota, increasing beneficial bacteria like Lachnospiraceae and Rikenellaceae, and altering Firmicutes, Proteobacteria, Bacteroidetes, and Lactobacillaceae ratios.

Conclusions:

  • Dietary sodium butyrate (SB) effectively improves broiler intestinal development, morphology, and function.
  • SB supplementation positively influences the gut microbial community, contributing to enhanced gut health.
  • Higher SB doses (800 mg/kg) appear to be optimal for modulating the gut microbiota and improving overall gut health in broilers.