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Related Experiment Video

Updated: Feb 10, 2026

Orthotopic Liver Transplantation in Rats

Orthotopic Liver Transplantation in Rats

Published on: July 1, 2012

The weekend effect in liver transplantation.

Felix Becker¹, Thomas Vogel¹, Thekla Voß¹

¹Department of General, Visceral and Transplant Surgery, University Hospital Münster, Münster, Germany.

|May 26, 2018

Summary

The weekend effect does not appear to impact orthotopic liver transplantation (oLT) outcomes. Patient and graft survival rates were similar for liver transplants performed on weekdays versus weekends.

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Area of Science:

Hepatology
Transplantation Surgery
Clinical Outcomes Research

Background:

The weekend effect is a documented phenomenon where hospital admissions on weekends are associated with increased patient risk.
Limited data exists on whether this effect extends to complex procedures like orthotopic liver transplantation (oLT).

Purpose of the Study:

To investigate the existence and impact of the weekend effect on orthotopic liver transplantation outcomes.
To compare one-year patient and graft survival rates for oLT performed on weekdays versus weekends.

Main Methods:

A retrospective analysis of deceased donor liver transplants performed between 2006 and 2016 in the Eurotransplant region.
Patients were categorized into weekday (Monday-Friday) and weekend (Saturday-Sunday) transplant groups.
One-year patient survival, graft survival, rejection rates, primary non-function, and re-transplantation rates were primary outcome measures.

Main Results:

A total of 364 deceased donor livers were transplanted into 329 patients; 246 (74.77%) on weekdays and 83 (25.23%) on weekends.
Key patient and donor characteristics, including age, ischemia time, and MELD score, were comparable between groups.
One-year patient and graft survival rates were similar, with no significant differences in rejection, primary non-function, or re-transplantation rates between weekday and weekend transplants.

Conclusions:

This study provides the first evidence from the Eurotransplant region indicating no weekend effect on orthotopic liver transplantation.
Standardized transplant protocols and specialized multidisciplinary teams may mitigate potential weekend-related risks.
Orthotopic liver transplantation is a safe and successful procedure, irrespective of the day of the week it is performed.