Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychology as a Science01:13

Psychology as a Science

4.0K
Psychology, as a scientific discipline, aims to understand the mind and behavior through rigorous and systematic methods. The foundation of psychological research is evidence-based, relying heavily on the scientific method to derive and validate knowledge. This structured approach ensures that findings are reliable, valid, and applicable to broader contexts.
The scientific method in psychology involves six critical steps: making observations, formulating hypotheses, conducting tests, analyzing...
4.0K
Overview of Biostatistics in Health Sciences01:19

Overview of Biostatistics in Health Sciences

5.3K
Biostatistics involves the application of statistical techniques to scientific research in health-related fields, including biology and public health. These techniques are essential for designing studies, collecting data, and analyzing it to draw meaningful conclusions. Given the complexity of biological processes, particularly in studies involving human subjects, biostatistical methods are crucial for effectively organizing and interpreting data that might otherwise obscure underlying patterns...
5.3K
Statistical Package for the Social Sciences (SPSS)01:22

Statistical Package for the Social Sciences (SPSS)

1.3K
The Statistical Package for the Social Sciences, or SPSS, is a data management and analysis software suite. Developed by SPSS Inc. in 1968 and acquired by IBM in 2009, this tool was initially designed for social science data analysis, evolving to serve a wider range of disciplines. It was later renamed to Statistical Product and Service Solutions.
SPSS streamlines the process from data preparation to analysis and reporting. It is characterized by its user-friendly interface, which conceals...
1.3K
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

1.0K
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
1.0K
Electronegativity02:54

Electronegativity

82.9K
Whether a bond is nonpolar or polar covalent is determined by a property of the bonding atoms called electronegativity. 
82.9K
Genomics02:02

Genomics

40.8K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

seqLens: Optimizing Language Models for Genomic Predictions.

Molecular biology and evolution·2026
Same author

Ordering molecular diversity in untargeted metabolomics via molecular community networking.

Cell reports methods·2026
Same author

Meta-analytic microbiome target discovery for immune checkpoint inhibitor response in advanced melanoma.

Communications medicine·2026
Same author

Local Nixtamalization Processes Reduce Aflatoxin B1 Concentration and Shift Metabolome in Naturally Contaminated Maize.

Journal of agricultural and food chemistry·2026
Same author

Longitudinal gut microbiome dynamics are associated with clinical outcome and toxicity during ibrutinib therapy.

Gut microbes·2026
Same author

Farnesoid X receptor-dependent microbiome-bile acid signaling mediates obstructive sleep apnea-induced atherosclerosis.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Feb 10, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

3.6K

American Gut: an Open Platform for Citizen Science Microbiome Research.

Daniel McDonald1, Embriette Hyde1, Justine W Debelius1

  • 1Department of Pediatrics, University of California San Diego, La Jolla, California, USA.

Msystems
|May 26, 2018
PubMed
Summary
This summary is machine-generated.

This large-scale citizen science project reveals the vast diversity of the human gut microbiome. It highlights how diet, particularly plant diversity, and life events like surgery significantly impact microbial communities.

More Related Videos

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome
08:38

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome

Published on: March 31, 2023

1.2K
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

23.7K

Related Experiment Videos

Last Updated: Feb 10, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
09:18

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

Published on: July 28, 2023

3.6K
Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome
08:38

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome

Published on: March 31, 2023

1.2K
Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
10:51

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

Published on: August 30, 2016

23.7K

Area of Science:

  • Microbiology
  • Human Health
  • Citizen Science

Background:

  • Integrating microbiome data from diverse projects is challenging.
  • The full extent of microbial and molecular diversity in human stool is largely unknown.
  • Standardized protocols are needed for robust microbiome research.

Purpose of the Study:

  • To compare human stool microbiome specimens from a large citizen-science cohort.
  • To investigate microbial and molecular diversity in the human gut.
  • To explore associations between the microbiome, metabolome, and dietary plant diversity.

Main Methods:

  • Utilized standardized protocols from the Earth Microbiome Project.
  • Collected over 10,000 human stool samples from citizen-scientists.
  • Employed an open research network for data integration and analysis.
  • Applied untargeted metabolomics to hundreds of samples.

Main Results:

  • Observed a wide range of beta-diversity in human stool microbiomes, exceeding environmental samples.
  • Identified procedures to correct for room-temperature shipping overgrowth, enabling phenotype correlations.
  • Discovered novel molecules and molecular communities within the human stool metabolome.
  • Confirmed associations between the microbiome and psychiatric illness and documented microbiome changes during surgery.

Conclusions:

  • Citizen science, using room-temperature shipped samples, can replicate and extend findings from clinical cohorts.
  • Individual microbiome changes, such as post-surgery, can be more significant than environmental biome differences.
  • Dietary plant diversity is a key factor influencing the human microbiome and metabolome.