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Updated: Jan 24, 2026
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Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
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Carbon ion radiotherapy for inoperable pediatric osteosarcoma.
Osama Mohamad1,2, Reiko Imai1, Tadashi Kamada1
1Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Oncotarget
|May 26, 2018
Summary
Carbon ion radiotherapy (CIRT) offers improved outcomes for unresectable pediatric osteosarcoma. This treatment demonstrated enhanced local control and overall survival compared to traditional methods, with manageable toxicity.
Area of Science:
- Oncology
- Radiation Oncology
- Pediatric Oncology
Background:
- Unresectable pediatric osteosarcoma presents significant treatment challenges.
- Conventional therapies yield poor outcomes for this aggressive malignancy.
Purpose of the Study:
- To evaluate the safety and efficacy of carbon ion radiotherapy (CIRT) for pediatric and adolescent patients with inoperable osteosarcoma.
Main Methods:
- Retrospective review of pediatric and adolescent patients treated with CIRT for inoperable osteosarcoma (1996-2014).
- Analysis of treatment outcomes including overall survival, local control, progression-free survival, and toxicity.
Main Results:
- CIRT demonstrated 5-year overall survival of 41.7% and local control of 62.9% in 26 patients.
- Largest tumor diameter was the only factor correlating with survival and local control.
- Low rates of severe late toxicity (4%) and no treatment-related mortalities were observed, with most patients maintaining ambulation.
Conclusions:
- CIRT is a safe and effective treatment for inoperable pediatric osteosarcoma.
- CIRT significantly improves local control and overall survival compared to conventional treatments.
- Further research into optimizing CIRT protocols for pediatric osteosarcoma is warranted.
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